TDGF1 Antibody

Product Specifications

Background

TDGF1 Antibody: Teratocarcinoma-derived growth factor 1 (TDGF1 or Cripto) is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. It is first expressed in the forming mesoderm during gastrulation but later in development the expression is restricted to the truncus arteriosus of the developing heart. This suggests that TDGF1 mediates the progression of epiblastic cells that give rise to the mesoderm. TDGF1 overexpression is characteristic of human gastric and colorectal carcinomas.

NCBI Gene ID

6997

Swiss Prot

P13385

Accession Number

NP_003203

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

TDGF1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

TDGF1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TDGF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

21 kDa

Fragment

IgG

Symbol

TDGF1

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

Teratocarcinoma-derived growth factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Brandt R, Normanno N, Gullick WJ, et al. Identification and biological characterization of an epidermal growth factor-related protein: Cripto-1. J. Biol. Chem. 1994; 269:17320-8.

Background Reference 02

Dono R, Scalera L, Pacifico F, et al. The murine Cripto gene: expression during mesoderm induction and early heart morphogenesis. Development 1993; 118:1157-68.

Background Reference 03

Parisi S, D'Andrea D, Lago CT, et al. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J. Cell Biol. 2003; 163:303-14.