PANX1 Antibody

Product Specifications

Background

PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

NCBI Gene ID

24145

Swiss Prot

Q96RD7

Accession Number

NP_056183

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell, Inflammasomes

Purification

PANX1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1316 - Human Ovary Tissue Lysate

Concentration

1 mg/mL

Buffer

PANX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PANX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

IgG

Specificity

Two transcript variants encoding different isoforms have been found for this gene.

Symbol

PANX1

Positive Control 2

Cat. No. 11-201 - Human Ovary Tissue Slide

NCBI Official Name

Pannexin 1

NCBI Organism

Homo sapiens

Background Reference 01

Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.

Background Reference 02

Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.