NGN2 Antibody

Product Specifications

Background

NGN2 Antibody: Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is thought to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been suggested for use in human embryonic neural progenitors as a graft for spinal cord injuries

NCBI Gene ID

63973

Swiss Prot

Q9H2A3

Accession Number

NP_076924

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

NGN2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

NGN2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NGN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

IgG

Specificity

NGN2 antibody is predicted to not cross-react with neurogenin 1.

Symbol

NEUROG2

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Neurogenin 2

NCBI Organism

Homo sapiens

Background Reference 01

Sommer L, Ma Q, and Anderson DJ. Neurogenins, a novel family of atonal-related bHLH transcription factors, a putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell Neurosci. 1996; 8:221-41.

Background Reference 02

Fode C, Gradwohl G, Morin X, et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 1998; 20:483-94.

Background Reference 03

Andersson EK, Irvin DK, Ahlsio J, et al. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Exp. Cell. Res. 2007; 313:1172-80.

Background Reference 04

Perrin FE, Boniface G, Serguera C, et al. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One 2010; 5:e15914.