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LMX1A Antibody

Product Specifications

Background

LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.

NCBI Gene ID

4009

Swiss Prot

Q8TE12

Accession Number

NP_796372

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

LMX1A Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (92%)

Buffer

LMX1A Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

LMX1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7087

Fragment

IgG

Specificity

At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.

Isoform

Human LMX1A has two isoforms, including isoform 1 (382aa, 42.7kD) and isoform 2 (133aa, 14.6kD) . Mouse LMX1A one isoform (382aa, 42.9kD), and ratt LMX1A has one isoform (382aa, 42.8kD) . 7087 can detect human, mouse and rat.

Symbol

LMX1A

Positive Control 2

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

Positive Control 3

Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

NCBI Official Name

LIM homeobox transcription factor 1, alpha

NCBI Organism

Homo sapiens

Background Reference 01

Failli et al. Mech. Dev. 2002; 118:225-8.

Background Reference 02

Nakatani et al. Biol. 2010; 339:101-13.

Background Reference 03

Chizhikov and Millen. Development 2004; 131:2693-705.

Background Reference 04

Lin et al. Am. J. Clin. Pathol. 2012; 137:971-7.

Other Product Names

LMX1A Antibody: LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha

Tested Applications

ELISA, ICC/IF, IHC-P, WB

Protein ID

28893581

Physical Properties

Liquid

Available Sizes

Curated Selection

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