SGSM1 Antibody

Product Specifications

Background

SGSM1 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1,148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.

NCBI Gene ID

129049

Swiss Prot

Q2NKQ1

Accession Number

NP_001035037

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

SGSM1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1362 - Human Cerebellum Tissue Lysate

Concentration

1 mg/mL

Buffer

SGSM1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SGSM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

126 kDa

Fragment

IgG

Specificity

At least four isoforms of SGSM1 are known to exist; SGSM1 antibody will detect all four isoforms.

Symbol

SGSM1

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Small G protein signaling modulator 1

NCBI Organism

Homo sapiens

Background Reference 01

Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.

Background Reference 02

Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13.

Background Reference 03

Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB) -mediated signaling pathway. Genomics 2007; 90:249-60.

Background Reference 04

Williams JA, Chen X and Sabbatini ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E405-14.