CLAUDIN4 Antibody

Product Specifications

Background

CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.

NCBI Gene ID

1364

Swiss Prot

O14493

Accession Number

NP_001296

Host

Rabbit

Reactivity

Human

Immunogen

7025

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 1) shows similar CLAUDIN4 expression profile in human cell lines detected by two independent anti-CLAUDIN4 antibodies that recognize different epitopes, 7025 against C-terminus domain and 24-028 against C-terminus domain. CLAUDIN4 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7025 24-028

Field of Research

Cancer, Cell Cycle

Purification

CLAUDIN4 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1219 - MCF7 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Mouse (94%) and Rat (88%) .

Buffer

CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CLAUDIN4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms

Isoform

Human CLAUDIN4 has one isoform (209aa, 22kD) . Mouse CLAUDIN4 has one isoform (210aa, 22kD) and Rat CLAUDIN4 also has one isoform (210aa, 22kD) . 7025 can detect human, mouse and rat.