EPM2A Antibody
Product Specifications
Background
EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
NCBI Gene ID
7957
Swiss Prot
O95278
Accession Number
NP_005661
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
EPM2A Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1221 - SW480 Cell Lysate
Concentration
1 mg/mL
Buffer
EPM2A Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
EPM2A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=7023
Calculated Molecular Weight
36 kDa
Fragment
IgG
Specificity
At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform.
Symbol
EPM2A
NCBI Official Name
Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
NCBI Organism
Homo sapiens
Background Reference 01
Minassian BA, Lee JR, Herbrick JA, et al. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat. Genet. 1998; 20:171-4.
Background Reference 02
Worby CA, Gentry MS, and Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J. Biol. Chem. 2006; 281:30412-8.
Other Product Names
EPM2A Antibody: EPM2, MELF, Laforin, Lafora PTPase, LAFPTPase
Tested Applications
ELISA, WB, ICC, IF
Protein ID
11321613
Physical Properties
Liquid
Available Sizes
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