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ANG Antibody

Product Specifications

Background

ANG Antibody: Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) . Angiogenin is a genetic link between ALS and PD.

NCBI Gene ID

283

Swiss Prot

P03950

Accession Number

NP_001136

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

ANG Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1464 - Rat Liver Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Horse: (75%)

Buffer

ANG Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ANG antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6983

Calculated Molecular Weight

16 kDa

Fragment

IgG

Specificity

Two alternatively spliced transcript variants have been observed.

Symbol

ANG

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Angiogenin, ribonuclease, RNase A family, 5

NCBI Organism

Homo sapiens

Background Reference 01

Moroianu J and Riordan JF. Identification of the nucleolar targeting signal of human angiogenin. Biochem. Biophys. Res. Commun. 1994; 203:1765-72.

Background Reference 02

Hu G, Riordan JF, and Vallee BL. Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities. Proc. Natl. Acad. Sci. USA 1994; 91:12096-100.

Background Reference 03

Pyatibratov MG and Kostyukova AS. New insights into the role of angiogenin in actin polymerization. Int. Rev. Cell. Mol. Biol. 2012; 295:175-98.

Background Reference 04

Li S, Ibaragi S, and Hu GF. Angiogenin as a molecular target for the treatment of prostate cancer. Curr. Cancer Ther. Rev. 2011; 7:83-90.

Other Product Names

ANG Antibody: ALS9, RAA1, HEL168, RNASE4, RNASE5, Angiogenin, Ribonuclease 5, RNase 5

Tested Applications

ELISA, WB, IF

Protein ID

4557313

Physical Properties

Liquid

Available Sizes

Curated Selection

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