CRIM1 Antibody
Product Specifications
Background
CRIM1 Antibody: CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
NCBI Gene ID
51232
Swiss Prot
Q9NZV1
Accession Number
NP_057525
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
CRIM1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Buffer
CRIM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CRIM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.
Symbol
CRIM1
Positive Control 2
Cat. No. 17-005 - Jurkat Cell Slide
NCBI Official Name
Cysteine rich transmembrane BMP regulator 1 (chordin-like)
NCBI Organism
Homo sapiens
Background Reference 01
Kolle G, Georgas K, Holmes GP, et al. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech. Dev. 2000; 90:181-93.
Background Reference 02
Glienke J, Sturz A, Menrad A, et al. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. Mech. Dev. 2002; 119:165-75.
Background Reference 03
Wilkinson L, Kolle G, Wen D, et al. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. J. Biol. Chem. 2003; 278:34181-8.
Background Reference 04
Pennisi DJ, Kinna G, Chiu HS, et al. Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta. Placenta 2012; 33:175-82.
Other Product Names
CRIM1 Antibody: S52, CRIM-1, S52, UNQ1886/PRO4330, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52
Tested Applications
ELISA, WB, IF
Protein ID
10092639
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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