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FAM193B Antibody

Product Specifications

Background

FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.

NCBI Gene ID

54540

Swiss Prot

Q96PV7

Accession Number

Q96PV7

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

FAM193B Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (81%)

Buffer

FAM193B Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FAM193B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6941

Calculated Molecular Weight

99 kDa

Fragment

IgG

Specificity

At least two isoforms of FAM193B are known to exist; this antibody will detect both isoforms.

Symbol

FAM193B

Positive Control 2

Cat. No. 17-005 - Jurkat Cell Slide

NCBI Official Name

Family with sequence similarity 193, member B

NCBI Organism

Homo sapiens

Background Reference 01

Picchione F, Pritchard C, Lagutina I, et al. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS) . Carcinogenesis 2011; 32:452-62.

Background Reference 02

Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008; 270:10-8.

Other Product Names

FAM193B Antibody: IRIZIO, KIAA1931, Protein FAM193B

Tested Applications

ELISA, WB, IF

Protein ID

205831282

Physical Properties

Liquid

Available Sizes

Curated Selection

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