CCDC22 Antibody

Product Specifications

Background

CCDC22 Antibody: CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID) .

NCBI Gene ID

28952

Swiss Prot

O60826

Accession Number

NP_054727

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

CCDC22 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

CCDC22 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CCDC22 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least three isoforms of CCDC22 are known to exist; this antibody will detect the two largest isoforms.

Symbol

CCDC22

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Coiled-coil domain containing 22

NCBI Organism

Homo sapiens

Background Reference 01

Tomsig JL, Snyder SL, and Creutz CE. Identification of targets for calcium signaling through the copine family of proteins. J. Biol. Chem. 2003; 278:10048-54.

Background Reference 02

Mulder J, Bjorling E, Jonasson K, et al. Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. Mol. Cell Prot. 2009; 8:1612-22.

Background Reference 03

Mulder J, Wernerus H, Shi TJ, et al. Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system. Neurosci.2007; 146:1689-703