BMP15 Antibody

Product Specifications

Background

BMP15 Antibody: BMP15, or GDF9B is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily that are involved in embryonic development and adult tissue homeostasis. BMP15 is expressed exclusively in the oocyte. It is an oocyte-specific growth/differentiation factor that may be involved in oocyte maturation and follicular development. Defects in BMP15 are the cause of ovarian dysgenesis type 2. BMP15 could be used as an oogenesis marker to track human amniotic fluid stem cells differentiation into the oocyte-like cells.

NCBI Gene ID

9210

Swiss Prot

O95972

Accession Number

NP_005439

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

BMP15 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1313 - Human Testis Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (75%), Sheep: (75%)

Buffer

BMP15 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

BMP15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

It is closely related to GDF9.

Symbol

BMP15

Positive Control 2

Cat. No. 17-201 - 3T3/BALB Cell Slide

NCBI Official Name

Bone morphogenetic protein 15

NCBI Organism

Homo sapiens

Background Reference 01

Massagué J. The transforming growth factor-beta family. Ann. Rev. Cell. Biol. 1990; 6:597-641

Background Reference 02

Aaltonen J, Laitinen MP, Vuojolainen K, et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early foliculogenesis. J. Clin. Endocrinol. Metab. 1999; 84:2744-50.

Background Reference 03

Laitinen M, Vuojolainen K, Jaatinen R, et al. A novel growth differentiation factor-9 (GDF-9) related factor is coexpressed with GDF-9 in mouse oocytes during folliculogenesis. Mech. Dev. 1998; 78:135-40.