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SDHAF1 Antibody

Product Specifications

Background

SDHAF1 Antibody: SDHAF1 (Succinate dehydrogenase complex assembly factor 1) is one of the subunits of the succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain. SDHAF1 resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency) . Unlike the related protein SDHAF2, SDHAF1 is not thought to be a tumor suppressor.

NCBI Gene ID

644096

Swiss Prot

A6NFY7

Accession Number

NP_001036096

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

SDHAF1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

Concentration

1 mg/mL

Buffer

SDHAF1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SDHAF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6879

Fragment

IgG

Specificity

SDHAF1 antibody is predicted to not cross-react with other SDHAF protein family members.

Symbol

SDHAF1

Positive Control 2

Cat. No. 17-201 - 3T3/BALB Cell Slide

NCBI Official Name

Succinate dehydrogenase complex assembly factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Ghezzi D, Goffrini P, Uziel G, et al. SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat. Genet. 2009; 41:654-6.

Background Reference 02

Hensen EE and Bayley JP. Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma. Fam. Cancer 2011; 10:355-63.

Other Product Names

SDHAF1 Antibody: LYRM8, LYRM8, Succinate dehydrogenase assembly factor 1, mitochondrial, LYR motif-containing protein 8, SDH assembly factor 1

Tested Applications

ELISA, WB, ICC, IF

Protein ID

111038124

Physical Properties

Liquid

Available Sizes

Curated Selection

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