FCHO2 Antibody

Product Specifications

Background

FCHO2 Antibody: FCHO2 (FCH domain only 2) is a ubiquitously expressed member of the FCFBS superfamily characterized by FES-CIP4 homology (FCH) domain, an FBH domain, and an SH3 domain. Both FCHO2 and the related protein FCHO1 are mediators of clathrin-mediated endocytosis, acting to sculpt the initial bud site and recruit the clathrin machinery for clathrin-coated vesicle formation. FCHO2 binds to Eps15, an important adaptor protein in clathrin-mediated endocytosis.

NCBI Gene ID

115548

Swiss Prot

Q0JRZ9

Accession Number

NP_620137

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

FCHO2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1461 - Rat Heart Tissue Lysate

Concentration

1 mg/mL

Buffer

FCHO2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FCHO2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

FCHO2 antibody is predicted to not cross-react with other FCHO protein family members. At least the isoforms of FCHO2 are known to exist; this antibody will detect only the two longest isoforms.

Symbol

FCHO2

Positive Control 2

Cat. No. 10-501 - Human Heart Tissue Slide

NCBI Official Name

FCH domain only 2

NCBI Organism

Homo sapiens

Background Reference 01

Katoh M and Katoh M. Identification and characterization of human FCHO2 and mouse fcho2 genes in silico. Int. J. Mol. Med. 2004; 14:327-31

Background Reference 02

Henne WM, Boucrot E, Meinecke M, et al. FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 2010; 328:1281-4.

Background Reference 03

Uezu A, Umeda K, Tsujita K, et al. Characterization of the EFC/F-BAR domain protein, FCHO2. Genes Cells 2011; 16:868-78.

Other Product Names

FCHO2 Antibody: FCH domain only protein 2

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

226371723

Physical Properties

Liquid

Available Sizes

Curated Selection

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