SHANK3 Antibody
Product Specifications
Background
SHANK3 Antibody: SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
NCBI Gene ID
85358
Swiss Prot
Q9BYB0
Accession Number
NP_001073889
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
SHANK3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Buffer
SHANK3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SHANK3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=6835
Fragment
IgG
Specificity
At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.
Symbol
SHANK3
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
SH3 and multiple ankyrin repeat domains 3
NCBI Organism
Homo sapiens
Background Reference 01
Sheng M and Kim E. The Shank family of scaffold proteins. J. Cell Sci. 2000; 113:1851-6.
Background Reference 02
Park E, Na M, Choi J. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J. Biol. Chem. 2004; 278:19220-9
Background Reference 03
Lim S, Naisbitt S, Yoon J, et al. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing and differential expression in brain and development. J. Biol. Chem. 1999; 274:29510-8.
Background Reference 04
Durand CM, Betancur C, Boeckers TM, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat. Genet. 2007; 39: 25-7.
Other Product Names
SHANK3 Antibody: PSAP2, SCZD15, PROSAP2, SPANK-2, DEL22q13.3, KIAA1650, PSAP2, SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2, Shank3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
122937241
Physical Properties
Liquid
Available Sizes
Curated Selection
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