SHANK3 Antibody

Product Specifications

Background

SHANK3 Antibody: SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.

NCBI Gene ID

85358

Swiss Prot

Q9BYB0

Accession Number

NP_001073889

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

SHANK3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

Concentration

1 mg/mL

Buffer

SHANK3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SHANK3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.

Symbol

SHANK3

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

SH3 and multiple ankyrin repeat domains 3

NCBI Organism

Homo sapiens

Background Reference 01

Sheng M and Kim E. The Shank family of scaffold proteins. J. Cell Sci. 2000; 113:1851-6.

Background Reference 02

Park E, Na M, Choi J. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J. Biol. Chem. 2004; 278:19220-9

Background Reference 03

Lim S, Naisbitt S, Yoon J, et al. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing and differential expression in brain and development. J. Biol. Chem. 1999; 274:29510-8.

Background Reference 04

Durand CM, Betancur C, Boeckers TM, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat. Genet. 2007; 39: 25-7.

Other Product Names

SHANK3 Antibody: PSAP2, SCZD15, PROSAP2, SPANK-2, DEL22q13.3, KIAA1650, PSAP2, SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2, Shank3