What is the catalog number for YPEL3 Antibody?

The catalog number for YPEL3 Antibody is 6775.

What sizes are available for YPEL3 Antibody?

YPEL3 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does YPEL3 Antibody come in?

YPEL3 Antibody is available in 2 different pack sizes.

Is YPEL3 Antibody in stock?

YPEL3 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

YPEL3 Antibody

Product Specifications

Background

YPEL3 Antibody: YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.

NCBI Gene ID

83719

Swiss Prot

P61236

Accession Number

NP_113665

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

YPEL3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1288 - A20 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

YPEL3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

YPEL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

YPEL3

Positive Control 2

Cat. No. 17-208 - A-20 Cell Slide

NCBI Official Name

Yippee-like 3

NCBI Organism

Homo sapiens

Background Reference 01

Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43.

Background Reference 02

Kelley K, Miller KR, Todd A, et al. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res. 2010; 70:3566-75.

Background Reference 03

Tuttle R, Simon R, Hitch DC, et al. Senescence-associated gene YPEL3 is downregulated in human tumors. Ann. Surg. Oncol. 2011; 18:1791-6.

Background Reference 04

Tuttle R, Miller KR, Maiorano JN, et al. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. Int. J. Cancer 2011; epub.