NKX2-8 Antibody

Product Specifications

Background

NKX2-8 Antibody: NKX2-8 (NK2 homeobox 8) is a member of a family of transcription factors that are involved in embryonic development and cell fate. It is expressed in the ventral foregut, the developing heart, the epithelial layers of the branchial arches and in the dorsal mesoderm. In conjunction with related protein, NKX2-5, NKX2-8 may play a role in cardiac embryonic development. NKX2-8 is also thought to be involved in lung development and is suspected of being an oncogene in lung cancer that is activated by way of gene amplification at chromosome 14q13.

NCBI Gene ID

26257

Swiss Prot

O15522

Accession Number

NP_055175

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

NKX2-8 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1464 - Rat Liver Tissue Lysate

Concentration

1 mg/mL

Buffer

NKX2-8 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NKX2-8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

NKX2-8 antibody is predicted to not cross-react with other NK2 homeobox family members.

Symbol

NKX2-8

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

NK2 homeobox 8

NCBI Organism

Homo sapiens

Background Reference 01

Boettger T, Stein S, and Kessel M. The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family. Dev. Genes Evol. 1997; 207:65-70.

Background Reference 02

Kendall J, Liu Q, Bakleh A, et al. Oncogenic ccooperation and coamplification of developmental transcription factor genes in lung cancer. Proc. Natl. Acad. Sci. USA 2007; 104:16663-8.

Background Reference 03

Hsu DS, Acharya CR, Balakumaran BS, et al. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. Proc. Natl. Acad. Sci. USA 2009; 106:5312-7.