NKX2-6 Antibody
Product Specifications
Background
NKX2-6 Antibody: NKX2-6 (NK2 homeobox 6) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-6 is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are thought to be a cause for some congenital heart abnormalities.
NCBI Gene ID
137814
Swiss Prot
A6NCS4
Accession Number
NP_001129743
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
NKX2-6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1401 - Mouse Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
NKX2-6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NKX2-6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=6751
Fragment
IgG
Specificity
NKX2-6 antibody is predicted to not cross-react with other NK2 homeobox family members. At least two isoforms of NKX2-6 are known to exist; this antibody will detect both isoforms
Symbol
NKX2-6
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
NK2 homeobox 6
NCBI Organism
Homo sapiens
Background Reference 01
Copeland NG, Jenkins NA, and Harvey RP. The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively. Genomics 1994; 22:655-6.
Background Reference 02
Tanaka M, Kasahara H, Bartunkova S, et al. Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev. Genet. 1998; 22:239-49.
Background Reference 03
Biben C, Hatzistavrou T, and Harvey RP. Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev. 1998; 73:125-7
Background Reference 04
Tanaka M, Schinke M, Liao HS, et al. Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol. Cell. Biol. 2001; 21:4391-8.
Other Product Names
NKX2-6 Antibody: CSX2, NKX2F, NKX4-2, Homeobox protein NK-2 homolog F
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
343183350
Physical Properties
Liquid
Available Sizes
Curated Selection
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