NKX2-4 Antibody

Product Specifications

Background

NKX2-4 Antibody: NKX2-4 (NK2 homeobox 4) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-4 is closely related to NKX2-1 and NKX2-4 and is specifically localized to the ventral diencephalon. Recent experiments in Xenopus have suggested that the homeodomain protein XANF is necessary for the activation of NKX2-4, but does not directly regulate its expression.

NCBI Gene ID

644524

Swiss Prot

Q9H2Z4

Accession Number

NP_149416

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

NKX2-4 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1288 - A20 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Guinea pig: (100%), Rat: (86%), Chicken: (86%), Bovine: (71%)

Buffer

NKX2-4 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NKX2-4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

NKX2-4 antibody is predicted to not cross-react with other NK2 homeobox family members. At least two isoforms of NKX2-4 are known to exist; this antibody will detect both isoforms.

Symbol

NKX2-4

Positive Control 2

Cat. No. 17-208 - A-20 Cell Slide

NCBI Official Name

NK2 homeobox 4

NCBI Organism

Homo sapiens

Background Reference 01

Wang CC, Brodnicki T, Copeland NG, et al. Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals. Mamm. Genome 2000; 11:466-8.

Background Reference 02

Small EM, Vokes SA, Garriock RJ, et al. Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes. Mech. Dev. 2000; 96:259-62.

Background Reference 03

Hill JT, Chao CS, Anderson KR, et al. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol. Endocrinol. 2010; 381-90.

Other Product Names

NKX2-4 Antibody: NKX2D, NKX2.4, NKX2D, Homeobox protein NK-2 homolog D

Tested Applications

ELISA, WB, ICC, IF

Protein ID

157426823

Physical Properties

Liquid

Available Sizes

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