GBP6 Antibody

Product Specifications

Background

GBP6 Antibody: The guanylate-binding proteins (GBPs), a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) (1,3) . GBP6 is induced by IFN and hydrolyzes GTP to both GDP and GMP. The precise function of GBP6 is still under investigation.

NCBI Gene ID

163351

Swiss Prot

Q6ZN66

Accession Number

NP_940862

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

GBP6 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

GBP6 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GBP6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

GBP6 antibody is predicted to not cross-react with other GBP family members.

Symbol

GBP6

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Guanylate binding protein family, member 6

NCBI Organism

Homo sapiens

Background Reference 01

Vestal DJ. The guanylate-binding proteins (GBPs) : proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.

Background Reference 02

Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.

Background Reference 03

Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.

Background Reference 04

Olszewski MA, Gray J, and Vestal DJ. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Interferon Cytokine Res. 2006; 26:328-52.