IRF2BP2 Antibody
Product Specifications
Background
IRF2BP2 Antibody: IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2) . IRF2BP2 is a direct target gene of p53 and is involved in cell survival during the p53 stress response, able to impede the p53-mediated transactivation of p21 and Bax. IRF2BP2 is also a co-factor of VGLL4 and is required to induce the expression of vascular endothelial growth factor A (VEGF-A) in muscle. It is normally found in the nucleus of skeletal muscle and cardiac cells, but can be found in the cytoplasm during skeletal muscle differentiation.
NCBI Gene ID
359948
Swiss Prot
Q7Z5L9
Accession Number
NP_892017
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
IRF2BP2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
IRF2BP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IRF2BP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both. This antibody is predicted to not cross-react with any FOXD4 protein family members.
Symbol
IRF2BP2
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Interferon regulatory factor 2 binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Childs KS and Goodbourn S. Identification of novel co-repressor molecules for interferon regulatory factor-2. Nuc. Acids Res. 2003; 31:3016-26
Background Reference 02
Koeppel M, van Heeringen SJ, Smeenk L, et al. The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response. Nuc. Acids Res. 2009; 37:322-35.
Background Reference 03
Teng ACT, Kuraitis D, Deeke SA, et al. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J. 2010; 24:4825-34.
Background Reference 04
Teng ACT, Al-montashiri NAM, Cheng BLM, et al. Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. PLoS One 2011; 6:e24100.
Other Product Names
IRF2BP2 Antibody: Interferon regulatory factor 2-binding protein 2, IRF-2-binding protein 2
Tested Applications
ELISA, WB, ICC
Protein ID
116734704
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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