Periphilin Antibody

Periphilin Antibody: Periphilin, known as PPHLN1 or gastric cancer antigen Ga50, plays a role in epithelial differentiation and contributes to epidermal integrity and barrier formation. It interacts with periplakin, a known precursor of the cornified cell envelope. Periphilin 1 is ubiquitously expressed and localizes to nucleus and cytoplasm. Existing as eight alternatively spliced isoforms, Periphilin is highly insoluble and contains a putative nuclear localization signal (NLS) within its N-terminal half, a prerequisite for the formation of insoluble complexes and a possible caspase recognition sequence and a potential nuclear export signal. Periphilin may play an important role in the nervous system.

Periphilin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Kazerounian S and Aho S. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. J. Biol. Chem. 2003; 278:36707-17.

Kurita M, Suzuki H, Masai H, et al. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem. Biophys. Res. Commun. 2004; 324:554-61

Soehn AS, Pham TT, Schaeferhoff K, et al. Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Genesis 2009; 47:697-707

Soehn AS, Franck T, Biskup S, et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics 2010; 11:203-15