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RUSC2 Antibody

Product Specifications

Background

RUSC2 Antibody: RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.

NCBI Gene ID

9853

Swiss Prot

Q8N2Y8

Accession Number

NP_055621

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

RUSC2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Buffer

RUSC2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RUSC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6659

Fragment

IgG

Specificity

At least three isoforms are known to exist; this antibody will detect all three isoforms. This antibody is predicted to not cross-react with RUSC1.

Symbol

RUSC2

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

RUN and SH3 domain containing 2

NCBI Organism

Homo sapiens

Background Reference 01

Bayer M, Fischer J, Kremerskthen J, et al. Identification and characterization of Iporin as a novel interaction partner for rab1. BMC Cell Biol. 2005; 29:6:15.

Background Reference 02

Katoh M and Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol. Rep. 2004; 12:933-8

Background Reference 03

Fukuda M, Kobayashi H, Ishibashi K, et al. Genome-wide investigation of the rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35. Cell Struct. Funct. 2011; 36:155-70

Other Product Names

RUSC2 Antibody: Iporin, KIAA0375, Iporin, Interacting protein of Rab1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

55741719

Physical Properties

Liquid

Available Sizes

Curated Selection

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