SPATA18 Antibody

SPATA18 Antibody: SPATA18, also known as SPETEX-1, was initially identified as a cytoplasmic protein of elongate spermatids that is thought to be involved in differentiation process of elongate spermatids to mature spermatozoa. Recent experiments have shown that SPATA18 is a transcriptional target of p53 and p63. It has also been suggested to play a role in mitochondria quality control by inducing intramitochondrial lysosome-like organella that eliminate oxidized mitochondrial proteins.

SPATA18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

At least three isoforms of SPATA18 are known to exist; this antibody will detect the two longest isoforms. SPATA18 antibody is predicted to not cross-react with other SPATA family members.

Iida H, Ichinose J, Kaneko T, et al. Complementary DNA cloning of rat spetex-1, a spermatid-expressing gene-1, encoding a 63 kDa cytoplasmic protein of elongate spermatids. Mol. Reprod. Dev. 2004; 68:385-93.

Bornstein C, Brosh R, Molchadsky A, et al. SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol. Cell Biol. 2011; 31:1679-89

Miyamoto Y, Kitamura N, Nakamura Y, et al. Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. PLoS One 2011; 6:e16054.