MS4A6A Antibody

MS4A6A Antibody: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other genes encoding membrane proteins, most having characteristic tetraspanning topology and similar intron/exon splice boundaries. All family members display unique expression patterns among hematopoietic cells and non-lymphoid tissues. The function of MS4A6A has been suggested to be involved in signal transduction as a component of a multimeric receptor complex in Alzheimer's disease and cancer.

MS4A6A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

At least three isoforms of MS4A6A are known to exist; this antibody will detect the two longer isoforms. MS4A6A antibody is predicted to not cross-react with MS4A family members.

Liang Y and Tedder TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 2001; 72:119-27

Ishibashi K, Suzuki M, Sasaki S, et al. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 2001; 264:87-93.

Antúnez C, Boada M, Gonzalez-Pérez A, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011; 3:33

Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011; 43:429-35.

MS4A6A Antibody: CDA01, MS4A6, 4SPAN3, CD20L3, MST090, MSTP090, 4SPAN3.2, CDA01, Membrane-spanning 4-domains subfamily A member 6A, CD20 antigen-like 3