DRGX Antibody

Product Specifications

Background

DRGX Antibody: DRGX, also known as DRG11 or PRRXL1, is a paired homeodomain transcription factor, and was initially cloned from a differential hybridization screen aimed at identifying dorsal root ganglia (DRG) -specific genes. DRGX is a key regulator of the differentiation of the spinal cord neuronal circuit dedicated to the processing of nociceptive information. DRGX is also important for the formation of the whisker-related somatosensory maps in the principal sensory nucleus of the trigeminal nerve, thalamus and somatosensory cortex.

NCBI Gene ID

644168

Swiss Prot

A6NNA5

Accession Number

NP_001073989

Host

Chicken

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

DRGX Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1464 - Rat Liver Tissue Lysate

Concentration

1 mg/mL

Buffer

DRGX Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DRGX antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Specificity

At least two are known to exist; DRGX antibody is predicted to not cross-react with other Homeodomain proteins.

Symbol

DRGX

NCBI Official Name

Dorsal root ganglia homeobox

NCBI Organism

Homo sapiens

Background Reference 01

Saito T, Greenwood A, Sun Q et al. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. Mol. Cell. Neurosci. 1995; 6:280-92.

Background Reference 02

Chen ZF, Rebelo S, White F et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 2001; 31:59-73.

Background Reference 03

Ding YQ, Yin J, Xu HM, et al. Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. J. Neurosci. 2003; 23:7246-54

Background Reference 04

Rebelo S, Lopes C, Lima D, et al. Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system. Int. J. Dev. Biol. 2009; 53:1089-95.