FCHSD1 Antibody

Product Specifications

Background

FCHSD1 Antibody: The FCH and double SH3 domains protein 1 (FCHSD1, also known as NWK2) and the related protein FCHSD2 were initially identified in silico as distantly related proteins to FNBP1 and FNBP2. Both share the common domain structure consisting of FCH, FBH, two SH3 and C-terminal proline-rich domains. While little is known of the function of FCHSD1, the related protein NWK is an adaptor protein that is thought to regulate Rho activity downstream of Robo receptors, suggesting that FCHSD1 may be involved in synaptic morphology by regulating actin dynamics in presynaptic terminals.

NCBI Gene ID

89848

Swiss Prot

Q86WN1

Accession Number

NP_258260

Host

Chicken

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

FCHSD1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1219 - MCF7 Cell Lysate

Concentration

1 mg/mL

Buffer

FCHSD1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FCHSD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Specificity

Multiple isoforms of FCHSD1 are known to exist. FCHSD1 antibody is predicted to not cross-react with FCHSD2

Symbol

FCHSD1

NCBI Official Name

FCH and double SH3 domains 1

NCBI Organism

Homo sapiens

Background Reference 01

Kato M and Kato M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int. J. Mol. Med. 2004; 13:749-54.

Background Reference 02

Coyle IP, Koh YH, Lee WC, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in drosophila. Neuron 2004; 41:521-34