FXYD7 Antibody

Product Specifications

Background

FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.

NCBI Gene ID

53822

Swiss Prot

P58549

Accession Number

AAH18619

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

FXYD7 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (71%)

Buffer

FXYD7 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FXYD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family

Symbol

FXYD7

NCBI Official Name

FXYD domain containing ion transport regulator 7

NCBI Organism

Homo sapiens

Background Reference 01

Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na, K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73

Background Reference 02

Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na, K-ATPase. Sci. STKE 2003; 2003 (166) :RE1.

Background Reference 03

Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na, K-ATPase. J. Biol. Chem. 2005; 280:42738-43.