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DBX1 Antibody

Product Specifications

Background

DBX1 Antibody: DBX1 is implicated in patterning the central nervous system during embryogenesis. DBX1 homeodomain transcription factor is expressed in progenitors which are critical in establishing cell fate allocation and cell diversity. DBX1 has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. DBX1-derived neurons are essential for the transgenic expression and generation of respiratory behavior both in vitro and in vivo.

NCBI Gene ID

120237

Swiss Prot

A6NMT0

Accession Number

NP_001025036

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

DBX1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (87%)

Buffer

DBX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DBX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6455

Fragment

IgG

Specificity

BX1 antibody is predicted to not cross-react with other DBX protein family members

Symbol

DBX1

Positive Control 2

Cat. No. 10-401 - Human Kidney Tissue Slide

NCBI Official Name

Developing brain homeobox 1

NCBI Organism

Homo sapiens

Background Reference 01

Griveau A, Borello U, Causeret F, et al. A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium. PLoS Biol. 2010; 8 (7) :e1000440

Background Reference 02

Causeret F, Ensini M, Teissier A, et al. Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One 2011; 6:e19367.

Background Reference 03

Pierani A, Moran-Rivard L, Sunshine MJ, et al. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron 2001; 29:367-84

Background Reference 04

Gray PA, Hayes JA, Ling GY, et al. Developmental origin of preBotzinger complex respiratory neurons. J. Neurosci. 2010; 30:14883-95.

Other Product Names

DBX1 Antibody: Homeobox protein DBX1, Developing brain homeobox protein 1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

304434796

Physical Properties

Liquid

Available Sizes

Curated Selection

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