KCNK13 Antibody

Product Specifications

Background

KCNK13 Antibody: The closely related proteins KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK13 is expressed mainly in the brain, but is also observed in kidneys. KCNK13 has been suggested to be a candidate for the Cs+-permeable K+ channel activated by GABA (B) receptors.

NCBI Gene ID

56659

Swiss Prot

Q9HB14

Accession Number

NP_071337

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

KCNK13 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

KCNK13 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KCNK13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

KCNK13 antibody is predicted to not cross-react with other KCNK protein family members.

Symbol

KCNK13

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Potassium channel, subfamily K, member 13

NCBI Organism

Homo sapiens

Background Reference 01

Rajan S, Wischmeyer E, Karschin C, et al. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem. 2001; 276:7302-11.

Background Reference 02

Jezzini SH and Moroz LL. Identification and distribution of a twopore domain potassium channel in the CNS of Aplysia californica. Brain Res. Mol. Brain Res. 2004; 127:27-38.

Background Reference 03

Theilig F, Goranova I, Hirsch JR, et al. Cellular localization of THIK-1 (K (2P) 13.1) and THIK-2 (K (2P) 12.1) K channels in the mammalian kidney. Cell Physiol. Biochem. 2008; 21:63-74

Background Reference 04

Ishii H, Nakajo K, Yanagawa Y, et al. Identification and characterization of Cs (+) -permeable K (+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. Eur. J. Neurosci. 2010; 32:736-48