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TMEM88 Antibody

Product Specifications

Background

TMEM88 Antibody: Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.

NCBI Gene ID

92162

Swiss Prot

Q6PEY1

Accession Number

EAW90125

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

TMEM88 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

TMEM88 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TMEM88 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.

Symbol

TMEM88

NCBI Official Name

Transmembrane protein 88

NCBI Organism

Homo sapiens

Background Reference 01

Lee HJ, Finklestein D, Li X, et al. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J. Biol. Chem. 2010; 285:41549-56.

Other Product Names

TMEM88 Antibody: TMEM88A, Transmembrane protein 88

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

44662813

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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