AP3S1 Antibody

Product Specifications

Background

AP3S1 Antibody: AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3 is an heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2) . AP3S1 Interacts with AGAP1 and may play an important role in carcinoma.

NCBI Gene ID

1176

Swiss Prot

Q92572

Accession Number

NP_001275

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

AP3S1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

AP3S1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

AP3S1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least three isoforms of AP3S1 are known to exist; this antibody will detect the two larger isoforms. AP3S1 antibody is predicted to not cross-react with other AP3 protein family members.

Symbol

AP3S1

Positive Control 2

Cat. No. 10-401 - Human Kidney Tissue Slide

NCBI Official Name

Adaptor-related protein complex 3, sigma 1 subunit

NCBI Organism

Homo sapiens

Background Reference 01

Watanabe TK, Shimizu F, Nagata M, et al. Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain. Cytogenet. Cell Genet. 1996; 73:214-7

Background Reference 02

Dell'Angelica EC, Ohno H, Ooi CE, et al. AP-3: an adaptor-like protein complex with ubiquitous expression. EMBO J. 1997; 16:917-28.

Background Reference 03

Zhou JB, Yang JK, Zhao L, et al. Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med. Sci. Monit. 2010; 16:BR179-83.

Background Reference 04

Petrenko AA, Pavlova LS, Karseladze AI, et al. Downregulation of genes encoding for subunits of adaptor complex-3 in cervical carcinomas. Biochemistry 2006; 71:1153-60