MEIG1 Antibody

Product Specifications

Background

MEIG1 Antibody: MEIG1, a murine gene first identified as a testis specific gene, is a chromosome/chromatin-binding protein initially expressed during meiosis but retained in the germ cell nucleus throughout later stages of spermatogenesis. MEIG1 is a highly conserved basal metazoan gene that is indispensable for mouse spermatogenesis. It is important for normal meiotic differentiation and absolutely crucial for terminal differentiation of spermatozoa. MEIG1 encodes two alternative transcripts, designated 2a2 and 11a2, both of which encode for a common ORF but differing in their 5' untranslated region (5'UTR) due to alternative promoters.

NCBI Gene ID

644890

Swiss Prot

Q5JSS6

Accession Number

Q5JSS6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

MEIG1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1402 - Mouse Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

MEIG1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MEIG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

MEIG1

NCBI Official Name

Meiosis expressed gene 1 homolog (mouse)

NCBI Organism

Homo sapiens

Background Reference 01

Don J and Wolgemuth DJ. Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992; 3:495-505

Background Reference 02

Salzberg Y, Eldar T, Karminsky OD, et al. Meig1 deficiency causes a severe defect in mouse spermatogenesis. Dev. Biol. 2010; 338:158-67.

Background Reference 03

Zhang Z, Shen X, Gude DR, et al. MEIG1 is essential for spermiogenesis in mice. Proc. Natl. Acad. Sci. USA 2009; 106:17055-60.

Background Reference 04

Ever L, Steiner R, Shalom S, et al. Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis. Cell Growth Differ. 1999; 10:19-26.