RASSF10 Antibody

Product Specifications

Background

RASSF10 Antibody: RASSF10 is a member of the N-terminal Ras association domain-containing family of proteins, a family of tumor suppressor genes that are frequently epigenetically inactivated in cancer. These proteins consist of RASSF7-10 and are structurally distinct from RASSF1-6, containing the N-terminal Ras association domain but lacking the Sav/RASSF/Hippo protein interaction domains. While little is known of the function of RASSF10, it is inactivated in both childhood leukemia and gliomas. In secondary glioblastomas, RASSF10 methylation can be used as an independent prognostic associated with worst progression-free survival and overall survival.

NCBI Gene ID

644943

Swiss Prot

A6NK89

Accession Number

NP_001073990

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

RASSF10 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

RASSF10 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RASSF10 antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

RASSF10 antibody will not cross-react with other RAS association domain-containing family members.

Symbol

RASSF10

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10

NCBI Organism

Homo sapiens

Background Reference 01

Sherwood V, Manbodh R, Sheppard C, et al. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol. Biol. Cell 2008; 19:1772-82.

Background Reference 02

Hesson LB, Dunwell TL, Cooper WC, et al. The novel RASSF6 and RASSF10 candidate tumor suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Mol. Cancer 2009; 8:42

Background Reference 03

Hill VK, Underhill-Day N, Krex D, et al. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene 2011; 30:30:978-89