Translin Antibody

Product Specifications

Background

Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

NCBI Gene ID

7247

Swiss Prot

Q15631

Accession Number

NP_004613

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Translin Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)

Buffer

Translin Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Translin antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least two isoforms of Translin are known to exist; this antibody will detect both.

Symbol

TSN

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Translin

NCBI Organism

Homo sapiens

Background Reference 01

Aoki K, Susuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat. Genet. 1995; 10:167-74.