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SGK1 Antibody

Product Specifications

Background

SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.

NCBI Gene ID

6446

Swiss Prot

O00141

Accession Number

NP_005618

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

SGK1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1319 - Human Stomach Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (89%), Chicken: (84%), Rabbit: (89%)

Buffer

SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SGK1 antibody can be stored at 4 ˚ C for 3 months and -20 ˚ C stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6319

Fragment

IgG

Specificity

SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist

Symbol

SGK1

Positive Control 2

Cat. No. 10-801 - Human Stomach Tissue Slide

NCBI Official Name

Serum/glucocorticoid regulated kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Webster MK, Goya L, Ge Y, et al. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell Biol. 1993; 13:2031-40.

Background Reference 02

Leong ML, Maiyar AC, Kim B, et al. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J. Biol. Chem. 2003; 278:5871-82.

Background Reference 03

Firestone GL, Giampaolo JR, O'Keeffe BA, et al. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell. Physiol. Biochem. 2003; 13:1-12.

Background Reference 04

Brunet A, Park J, Tran H, et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) . Mol. Cell Biol. 2001; 21:952-65.

Other Product Names

SGK1 Antibody: SGK, SGK

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

25168263

Physical Properties

Liquid

Available Sizes

Curated Selection

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