DYRK2 Antibody
Product Specifications
Background
DYRK2 Antibody: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
NCBI Gene ID
8445
Swiss Prot
Q92630
Accession Number
NP_006473
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
DYRK2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (89%), Mouse: (89%)
Buffer
DYRK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DYRK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Two isoforms of DYRK2 are known to exist; this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.
Symbol
DYRK2
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Becker W, Weber Y, Wetzel K, et al. Sequence characteristics, subcellular localization, and substrate specificity of DRYK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 1998; 273:25893-902.
Background Reference 02
Yoshida K. Role for DYRK family kinases on regulation of apoptosis. Biochem. Pharmacol. 2008; 76:1389-94.
Background Reference 03
Taira N, Yamamoto H, Yamaguchi T, et al. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage J. Biol. Chem. 2010; 285:4909-19.
Other Product Names
DYRK2 Antibody: Dual specificity tyrosine-phosphorylation-regulated kinase 2
Tested Applications
ELISA, WB, ICC, IF
Protein ID
4503427
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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