SLAMF4 Antibody

Product Specifications

Background

SLAMF4 Antibody: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.

NCBI Gene ID

51744

Swiss Prot

Q9BZW8

Accession Number

NP_1160135

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

SLAMF4 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1224 - Daudi Cell Lysate

Concentration

1 mg/mL

Buffer

SLAMF4 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLAMF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.

Symbol

CD244

NCBI Official Name

CD244 molecule, natural killer cell receptor 2B4

NCBI Organism

Homo sapiens

Background Reference 01

Claus M, Meinke S, Bhat R, et al. Regulation of NK cell activity by 2B4, NTB-A and CRACC. Front. Biosci. 2008; 13:956-65.

Background Reference 02

Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.

Background Reference 03

Assarsson E, Kambayashi T, Persson CM, et al. 2B4/CD48-mediated regulation of lymphocyte activation and function. J. Immunol. 2005; 175:2045-9

Background Reference 04

Kim JR, Matther SO, Patel RK, et al. Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythmatosus. Clin. Exp. Immunol. 2010; 160:348-58