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SLAMF2 Antibody

Product Specifications

Background

SLAMF2 Antibody: The signaling lymphocyte-activation molecule family member 2 (SLAMF2), also known as CD48, is a GPI-anchored protein that exists as both a soluble and membrane-associated form and is expressed in almost all leukocyte populations particularly in mitogen-stimulated human lymphocytes. SLAMF2 is a high-affinity ligand for SLAMF4, also known as 2B4, as well as a low-affinity ligand for CD2, and can thus can stimulate cells expressing these receptors. It has been shown to be an IL-3-induced activating receptor on eosinophils and is likely to be involved in promoting allergic inflammation. SLAMF2 is also thought to be involved in the IL-18/IL-18R signaling cascade in T and natural killer cells to produce interferon-gamma.

NCBI Gene ID

962

Swiss Prot

P09326

Accession Number

NP_1769

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

SLAMF2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

SLAMF2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLAMF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6249

Fragment

IgG

Specificity

Two isoforms of SLAMF2 are known to exist; this antibody will recognize both isoforms. SLAMF2 antibody is predicted to not cross-react with other SLAM protein family members.

Symbol

CD48

NCBI Official Name

CD48 molecule

NCBI Organism

Homo sapiens

Background Reference 01

Smith GM, Biggs J, Norris B, et al. Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis. J. Clin. Immunol. 1997; 17:502-9.

Background Reference 02

Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.

Background Reference 03

Munitz A, Bachelot I, Eliashar R, et al. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J. Immunol. 2006; 177:77-83.

Background Reference 04

Fukushima K, Ikehara Y, and Yamashita K. Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. J. Biol. Chem. 2005; 280:18056-62.

Other Product Names

SLAMF2 Antibody: BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102, BCM1, CD48 antigen, B-lymphocyte activation marker BLAST-1

Tested Applications

ELISA, WB

Protein ID

21361571

Physical Properties

Liquid

Available Sizes

Curated Selection

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