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SLAMF1 Antibody

Product Specifications

Background

SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP) .

NCBI Gene ID

6504

Swiss Prot

Q13291

Accession Number

NP_003028

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

SLAMF1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1472 - Rat Colon Tissue Lysate

Concentration

1 mg/mL

Buffer

SLAMF1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLAMF1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6247

Fragment

IgG

Specificity

4 isoforms of SLAMF1 are known to exist; this antibody will is predicted to recognize all 4 isoforms. SLAMF1 antibody is predicted to not cross-react with other SLAM protein family members.

Symbol

SLAMF1

NCBI Official Name

Signaling lymphocytic activation molecule family member 1

NCBI Organism

Homo sapiens

Background Reference 01

Cocks BG, Chang CC, Carballido JM, et al. 1995. A novel receptor involved in T cell activation. Nature 1995; 376:260-3.

Background Reference 02

Tatsuo H, Ono N, Tanaka K, et al. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000; 406:893-7.

Background Reference 03

Aversa G, Chang CC, Carballido JM, et al. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, Cyclosporin A-sensitive T cell proliferation and IFN-α production. J. Immunol. 1997; 158:4036-44.

Other Product Names

SLAMF1 Antibody: SLAM, CD150, CDw150, SLAM, Signaling lymphocytic activation molecule

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4506969

Physical Properties

Liquid

Available Sizes

Curated Selection

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