Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TM4SF1 Antibody

Product Specifications

Background

TM4SF1 Antibody: TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

NCBI Gene ID

4071

Swiss Prot

P30408

Accession Number

NP_055035

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

TM4SF1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

TM4SF1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TM4SF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6229

Fragment

IgG

Specificity

At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.

Symbol

TM4SF1

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Transmembrane 4 L six family member 1

NCBI Organism

Homo sapiens

Background Reference 01

Marken JS, Schieven GL, Hellstrom I, et al. Cloning and expression of the tumor-associated antigen L6. Proc. Natl. Acad. Sci. USA 1992; 89:3503-7

Background Reference 02

Romanska HM and Berditchevski F. Tetraspanins in human epithelial malignancies. J. Pathol. 2011; 223:4-14

Background Reference 03

Shih SC, Zukauskas A, Li D, et al. The L6 TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 2009; 69:3272-7.

Other Product Names

TM4SF1 Antibody: L6, H-L6, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

21265101

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NFKB1 Rabbit Polyclonal Antibody
AP02560PU-S 50 µL

NFKB1 Rabbit Polyclonal Antibody

Ask
View Details
Lyn Antibody
14-007 100 µL

Lyn Antibody

Ask
View Details
TAT-amide
MBS5789408 Inquire

TAT-amide

Ask
View Details
SCP3 (SYCP3) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3D6]
TA806547BM 100 µL

SCP3 (SYCP3) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3D6]

Ask
View Details