MYOZAP Antibody

Product Specifications

Background

MYOZAP Antibody: MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A) . Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.

NCBI Gene ID

100820829

Swiss Prot

P0CAP1

Accession Number

NP_001018110

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

MYOZAP Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1465 - Rat Kidney Tissue Lysate

Concentration

1 mg/mL

Buffer

MYOZAP Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MYOZAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

Multiple isoforms of MYOZAP are known to exist.

Symbol

MYZAP

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Myocardial zonula adherens protein

NCBI Organism

Homo sapiens

Background Reference 01

Van Tintelen JP, Hofstra RM, Wiesfeld AC, et al. Molecular genetics of arrhythmogenic right ventricular cardiomyopathy: emerging horizon? Curr. Opin. Cardiol. 2007; 22:185-92.

Background Reference 02

Seeger TS, Frank D, Rohr C, et al. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ. Res. 2010; 106:880-90.

Background Reference 03

Roginski RS, Mohan Raj BK, Birditt B, et al. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. Genomics 2004; 84:265-76.