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RBM35B Antibody

Product Specifications

Background

RBM35B Antibody: RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs, suggesting that these proteins are global regulators of an epithelial regulatory network. Loss of this global ESRP-regulated epithelial splicing programme induces the phenotypic changes in cell morphology that are observed during the epithelial-mesenchymal transition.

NCBI Gene ID

80004

Swiss Prot

Q9H6T0

Accession Number

NP_079215

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

RBM35B Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1302 - Human Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (80%)

Buffer

RBM35B Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RBM35B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6187

Fragment

IgG

Specificity

RBM35B antibody is predicted to not cross-react with other RBM35/ESRP family members. At least two isoforms of RBM35B are known to exist; this antibody will detect both isoforms.

Symbol

ESRP2

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Epithelial splicing regulatory protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Warzecha CC, Sato TK, Nabet B, et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell. 2009; 33:591-601.

Background Reference 02

Warzecha CC, Jiang P, Amirikian K, et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 2010; 29:3286-300.

Background Reference 03

Warzecha CC, Shen S, Xing Y, et al. The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biol. 2009; 6:546-62.

Other Product Names

RBM35B Antibody: RBM35B, RBM35B, PP7059, Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

45935393

Physical Properties

Liquid

Available Sizes

Curated Selection

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