OGFOD2 Antibody

Product Specifications

Background

OGFOD2 Antibody: OGFOD2 is a member of the 2-OG-Fe (II) dioxygenase family which plays an important role in ischemic survival and stress. Like the related protein OGFOD1, OGFOD2 is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. Little is known about the function of OGFOD2, but its similarity to OGFOD1 suggests that it is a novel stress granule component that may play an important proapoptotic role in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.

NCBI Gene ID

79676

Swiss Prot

Q6N063

Accession Number

NP_078899

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

OGFOD2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

OGFOD2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

OGFOD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

OGFOD2 antibody is predicted to not cross-react with other TPA1 protein family members. At least three isoforms are known to exist; this antibody will only detect the two larger isoforms.

Symbol

OGFOD2

NCBI Official Name

2-oxoglutarate and iron-dependent oxygenase domain containing 2

NCBI Organism

Homo sapiens

Background Reference 01

Saito K, Adachi N, Koyama H et al. OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. FEBS Lett. 2010; 584:3340-7.

Background Reference 02

Wehner KA, Schutz S and Sarnow P. OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. Mol. Cell. Biol. 2010; 30:2006-16.

Background Reference 03

Marina O, Hainz U, Biernacki MA, et al. Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens. Cancer Res. 2010; 70:1344-55.