What is the catalog number for PION Antibody?

The catalog number for PION Antibody is 6161.

What sizes are available for PION Antibody?

PION Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does PION Antibody come in?

PION Antibody is available in 2 different pack sizes.

Is PION Antibody in stock?

PION Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

PION Antibody

Product Specifications

Background

PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99) . The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.

NCBI Gene ID

54103

Swiss Prot

A4D1B5

Accession Number

NP_059135

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

PION Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1287 - EL4 Cell Lysate

Concentration

1 mg/mL

Buffer

PION Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PION antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.

Symbol

PION

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Pigeon homolog (Drosophila)

NCBI Organism

Homo sapiens

Background Reference 01

Ponte P, Gonzalez-DeWhitt P, Schilling J, et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature1988; 331:525-77.