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ZMYM4 Antibody

Product Specifications

Background

ZMYM4 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3'UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN-γ -induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.

NCBI Gene ID

9202

Swiss Prot

Q5VZL5

Accession Number

AAI27114

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

ZMYM4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (94%)

Buffer

ZMYM4 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ZMYM4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=6139

Calculated Molecular Weight

167 kDa

Fragment

IgG

Specificity

At least three isoforms of ZMYM4 are known to exist; this antibody will detect all of them. ZMYM4 antibody is predicted not to cross-react with other ZMYM family members.

Symbol

ZMYM4

NCBI Official Name

Zinc finger, MYM-type 4

NCBI Organism

Homo sapiens

Background Reference 01

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.

Background Reference 02

Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.

Background Reference 03

Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→ q12. Cytogenet. Cell Genet. 2000; 89:24-8.

Background Reference 04

McDoniels-Silvers AL, Nimri CF, Stoner GD, et al. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin. Cancer Res. 2002; 8:1127-38.

Other Product Names

ZMYM4 Antibody: MYM, CDIR, ZNF262, ZNF198L3, KIAA0425, Zinc finger MYM-type protein 4, Zinc finger protein 262

Tested Applications

ELISA, IHC-P

Protein ID

117558167

Physical Properties

Liquid

Available Sizes

Curated Selection

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