ZMYM3 Antibody

Product Specifications

Background

ZMYM3 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.

NCBI Gene ID

9203

Swiss Prot

Q14202

Accession Number

AAH69057

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

ZMYM3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

ZMYM3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ZMYM3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.

Symbol

ZMYM3

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Zinc finger, MYM-type 3

NCBI Organism

Homo sapiens

Background Reference 01

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.

Background Reference 02

Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21

Background Reference 03

Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→ q12. Cytogenet. Cell Genet.2000; 89:24-8.

Background Reference 04

Van der Maarel SM, Scholten IH, Huber I, et al. Cloning and characterization of DSX6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum. Mol. Gen.1996; 5:887-97.