ZMYM2 Antibody

Product Specifications

Background

Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression (1) . The protein folding and the DNA binding ability are governed by the coordination of a zinc ion (1-3) . As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes (4) . Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) (5) .

NCBI Gene ID

7750

Swiss Prot

Q9UBW7

Accession Number

CAH71822

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

ZMYM2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

ZMYM2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ZMYM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least two isoforms of ZMYM2 are known to exist; this antibody will detect only the longest isoform. ZMYM2 antibody is predicted to not cross-react with other ZMYM protein family members.

Symbol

ZMYM2

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Zinc finger, MYM-type 2

NCBI Organism

Homo sapiens

Background Reference 01

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.

Background Reference 02

Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.

Background Reference 03

Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet. 2000; 89:24-8