SYNPO2L Antibody

Product Specifications

Background

SYNPO2L Antibody: SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.

NCBI Gene ID

79933

Swiss Prot

Q9H987

Accession Number

BAD37139

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

SYNPO2L Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1314 - Human Thymus Tissue Lysate

Concentration

1 mg/mL

Buffer

SYNPO2L Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SYNPO2L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

SYNPO2L

NCBI Official Name

Synaptopodin 2-like

NCBI Organism

Homo sapiens

Background Reference 01

Beqqali A, Kloots J, Ward-van Oostward D, et al. Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells2006; 24:1956-67.

Background Reference 02

Beqqali A, Manshouwer-Kloots J, Moneiro R, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J. Cell Sci.2010; 123:1141-50.